Zolpidem induced a weak, biphasic dose-dependent antinociceptive effect, antagonized primarily by the non-selective opioid antagonist naloxone and by yohimbine. Zopiclone induced a weak, dose-dependent antinociceptive effect, antagonized only by the alpha2-adrenergic receptor antagonist yohimbine. Our results demonstrate a significant difference between the antinociceptive properties of zopiclone and zolpidem when injected s.c. Their possible antinociceptive effect and interaction with the opioid system has not been studied yet. The "Z compounds" are considered to cause less significant rebound insomnia or tolerance than the conventional hypnotic benzodiazepines. Their use for the treatment of short-term insomnia has been expanding constantly during the last two decades. Zolpidem and zopiclone are two of a newer hypno-sedative class of drugs, the "Z compounds". Pick, Chaim G Chernes, Yakov Rigai, Tova Rice, Kenner C Schreiber, Shaul The antinociceptive effect of zolpidem and zopiclone in mice. These results suggest that zolpidem may prove to be a safer hypnotic drug which has fewer or milder side effects than are benzodiazepine and cyclopyrrolone hypnotics. Zolpidem, unlike triazolam and zopiclone, had a much milder reducing-effect on the frequency of hippocampal theta activity and suppressing-effect on REM sleep. Polygraphic sleep recording and visual frequency analysis of the hippocampal EEG activity in REM sleep were carried out for 6 h after each injection. Rats were injected intraperitoneally with these drugs or their vehicle. Rats were divided into triazolam treatment group (1 mg/kg, 5 mg/kg), zopiclone treatment group (20 mg/kg, 100 mg/kg) and zolpidem treatment group (20 mg/kg, 100 mg/kg). In order to investigate the relative efficacy and safety of zopiclone and zolpidem, we compared the effects of higher doses of zopiclone and zolpidem on the frequency of hippocampal theta activity and sleep structure with that of triazolam. Yoshimoto, M Higuchi, H Kamata, M Yoshida, K Shimizu, T Hishikawa, Y ![]() The effects of benzodiazepine (triazolam), cyclopyrrolone ( zopiclone) and imidazopyridine ( zolpidem) hypnotics on the frequency of hippocampal theta activity and sleep structure in rats.
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